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 The building blocks of
CapsuTech’s polymers are made of a targeting entity linked to an amino acid
polymeric backbone that, in turn, is modified with cyclodextrins that form
molecular pockets. Beyond the targeting features, this structure allows for the
combination of two models of interaction: whereas the whole peptide wraps
itself around the guest molecule, the molecular pockets interact with specific
molecular bulges projected from the backbone of the guest molecule, and if the
guest molecule is small enough it can even be entirely contained by one or two
pocket sites. Once covered with the polymer and hidden in the molecular
pockets, the guest molecule is protected from degradation or chemical
modifications due to pH, light, oxidation, temperature and other damaging
factors. Furthermore, many drugs demonstrate poor or limited water or blood
solubility, and thus, the vehicle may play an important role in improving drug
solubility. Finally, there are no covalent bonds between the drug and the
vehicle so there are no changes in drug characteristics.
Furthermore, our polymers are made of the 20 amino-acid building blocks.
Therefore, maximum guest-polymer adjustment is enabled in a semi tailor-made
manner using various combinations of the building blocks and different levels
of modification by the molecular pockets. The presence of targeting moieties
and specific cleavage sites are added to form even smarter polymer. An example
of such smart polymer might be one that can target chemotherapy to breast
cancer cells by bearing breast cancer specific antibodies. As collagenases are
secreted mainly from cancer cells, the polymer can be designed to be cleaved
only by cancer cells by including collagen sequences in the polymer. In
addition, it is also possible to design the polymer for controlled release of
the guest molecule at a certain rate after being specifically cleaved by the
cancer cells.
In summary, the polymers that CapsuTech develops respond to the vast needs required by the next generation of encapsulating molecules. They are made of flexible and variant backbone that can be manipulated according to a wide spectrum of needs and tasks.
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